Postdoc in CRISR-Cas engineering and tool development

Solliciteer nu
Post-doc Researcher

Postdoc in CRISR-Cas engineering and tool development

Deze vacature is alleen beschikbaar in het Engels

The research is aimed at engineering and developing CRISPR-Cas genome editing tools for pharmaceuticals and agriculture. We offer a stimulating research environment for a postdoc interested in CRISPR-Cas and genome editing. The department’s research laboratories are well equipped for molecular biology, enzymology, protein engineering, cell biology and genome editing work.

Faculty of Science and Engineering
Solliciteer uiterlijk: 12 October 2026 23:59 Dutch local time
1 fte
€4.251 - €4.422

Postdoc in CRISR-Cas engineering and tool development

Solliciteer nu
afbeelding van medewerker

What are you going to do?

Project aim

CRISPR-Cas systems are adaptive immune systems found in bacteria against mobile genetic elements, such as viruses. CRISPR-Cas nucleases have proven to be effective at targeting and cleaving DNA, leading them to be repurposed for genome editing and is currently a widely used tool in many fields such as biotechnology and biomedical sciences. While these native CRISPR-Cas nucleases have been game-changers, they often fall short of perfection when it comes to applications like gene therapy.

The main aim of the project is to engineer, optimize and design CRISPR-Cas nuclease for specific therapeutic targets in a high throughput manner, with the goal of advancing gene therapy applications.

  • Design and clone plasmids
  • Purify proteins in E. coli
  • Perform in vitro biochemical assays to assess DNA cleavage activity
  • Develop and perform miniaturized high-throughput screening in E. coli, mammalian cell lines and biochemical assays
  • Evaluate activity of genome editing systems in bacterial cells and mammalian cell lines 

Who are you?

We are looking for enthusiastic and talented postdoc candidates with

Essential qualifications

  • A PhD degree in Biotechnology, Biochemistry, Cell Biology or a related field 
  • Research experience in molecular biology (molecular cloning), E. coli culturing and protein purification. 
  • Capacity to think analytically and creatively
  • High motivation
  • Ability to work in an international team
  • An integrative and cooperative personality with excellent communication and social skills
  • Fluency in English – written and oral.

Preferred qualifications

  • Previous hands on experience with CRISPR-Cas, mammalian cell culture, FACS or next generation sequencing preferred but not required
  • Familiarity with standard bioinformatic tools (Pymol/Python/command-line based) 

What can you expect from us?

  • In accordance with the collective labor agreement for Dutch universities, we offer a salary of at least € 4.251 up to a maximum of € 4.422 (salary scale 10.4) gross per month for a full-time employment contract.
  • 232 vacation hours per year, based on a 38-hour workweek (1.0 FTE). You can also work more or fewer hours in exchange for more or fewer free hours. For example, with a 40-hour workweek, you save 96 extra free hours, and with a 36-hour workweek, you lose 96 hours.
  • End-of-year bonus of 8.3% and 8% holiday allowance.
  • Extensive opportunities for personal and professional development.
  • In total a 6 months contract duration.
afbeelding van medewerker

Where will you be working?

At the University of Groningen (UG), researchers from all fields of academia and technology are working on academic challenges and societal questions. Lecturers prepare their students for meaningful careers within or outside the academic world. Interdisciplinary research and teaching, sharing of knowledge, collaboration with businesses, government institutions, and societal organizations are aspects that are of the utmost importance to this European top university. The UG aims to be an open academic community with an inclusive and safe working climate that invites you to add your value.

De Faculty of Science and Engineering (FSE) verzorgt onderwijs en onderzoek in een breed spectrum van disciplines, van natuurkunde en biologie tot kunstmatige intelligentie, werktuigbouwkunde en farmacie. We dragen in nauwe samenwerking met partners uit bedrijfsleven, medische wereld en maatschappij bij aan de urgente uitdagingen van onze tijd, zoals energie, duurzaamheid, digitalisering en medische technologie. Onze gemeenschap heeft een open en informeel karakter, met meer dan 7.000 studenten, 1.000 promovendi en 1.400 medewerkers van over de hele wereld. Wil je meer weten over de Faculty of Science and Engineering? Kijk dan op rug.nl/fse.

The vacancy is within the group of Assis. Prof. Dr. Wen Wu at the Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, which is located on the UMCG campus in Groningen.

Application procedure

Step 1: Jouw sollicitatie

Nadat je jouw sollicitatie hebt ingediend, ontvang je een bevestiging per mail.

Step 2: Selectie

De selectiecommissie beoordeelt je sollicitatie en laat je zo spoedig mogelijk weten of je wordt uitgenodigd voor een gesprek.

Step 3: Eerste gesprek

We leren elkaar graag beter kennen tijdens een eerste gesprek, dat zowel online als op locatie kan plaatsvinden.

Step 4: Tweede gesprek en mogelijk assessment of gastcollege

Mogelijk plannen we nog een tweede gesprek met je in. Dit gesprek kan, afhankelijk van de functie, worden aangevuld met een assessment of gastcollege.

Step 5: Het arbeidsvoorwaardengesprek

Na een positief gesprek, nemen we samen de arbeidsvoorwaarden door. Als alles rond is, heten we je van harte welkom bij de Rijksuniversiteit Groningen!

Interested?

Does this vacancy appeal to you? If so, click on the button below and apply straightaway.

Please add the following documents to your application:

  • CV

  • cover letter

afbeelding van medewerker

Do you have any questions or need more information?

  • Questions about the content of the job?

    Wen Wu

    Assistant Professor

    w.y.wu@rug.nl
  • Questions about your application process?

    Friso Salverda

    Human Resources Adviser

    f.d.salverda@rug.nl

Information about applying

When scheduling meetings, we will take your schedule into account as much as possible.

The University of Groningen considers social safety important. We strive to be a university where staff and students feel respected and at home, regardless of differences in background, experiences, perspectives, and identity. For more information, see also our page about our diversity policy.

Acquisition is not appreciated.

Our selection procedure follows the guidelines of the NVP Application Code.

Read document

Als eerste op de hoogte van vacatures bij de RUG

Meld je aan voor de vacaturealert en mis geen enkele vacature.

Aanmelden voor vacaturealert