Postdoc in CRISR-Cas engineering and tool development
Solliciteer nuPostdoc in CRISR-Cas engineering and tool development
The research is aimed at engineering and developing CRISPR-Cas genome editing tools for pharmaceuticals and agriculture. We offer a stimulating research environment for a postdoc interested in CRISPR-Cas and genome editing. The department’s research laboratories are well equipped for molecular biology, enzymology, protein engineering, cell biology and genome editing work.
Postdoc in CRISR-Cas engineering and tool development
Solliciteer nu
What are you going to do?
Project aim
CRISPR-Cas systems are adaptive immune systems found in bacteria against mobile genetic elements, such as viruses. CRISPR-Cas nucleases have proven to be effective at targeting and cleaving DNA, leading them to be repurposed for genome editing and is currently a widely used tool in many fields such as biotechnology and biomedical sciences. While these native CRISPR-Cas nucleases have been game-changers, they often fall short of perfection when it comes to applications like gene therapy.
The main aim of the project is to engineer, optimize and design CRISPR-Cas nuclease for specific therapeutic targets in a high throughput manner, with the goal of advancing gene therapy applications.
- Design and clone plasmids
- Purify proteins in E. coli
- Perform in vitro biochemical assays to assess DNA cleavage activity
- Develop and perform miniaturized high-throughput screening in E. coli, mammalian cell lines and biochemical assays
- Evaluate activity of genome editing systems in bacterial cells and mammalian cell lines
Who are you?
We are looking for enthusiastic and talented postdoc candidates with
Essential qualifications
- A PhD degree in Biotechnology, Biochemistry, Cell Biology or a related field
- Research experience in molecular biology (molecular cloning), E. coli culturing and protein purification.
- Capacity to think analytically and creatively
- High motivation
- Ability to work in an international team
- An integrative and cooperative personality with excellent communication and social skills
- Fluency in English – written and oral.
Preferred qualifications
- Previous hands on experience with CRISPR-Cas, mammalian cell culture, FACS or next generation sequencing preferred but not required
- Familiarity with standard bioinformatic tools (Pymol/Python/command-line based)
What can you expect from us?
- In accordance with the collective labor agreement for Dutch universities, we offer a salary of at least € 4.251 up to a maximum of € 4.422 (salary scale 10.4) gross per month for a full-time employment contract.
- 232 vacation hours per year, based on a 38-hour workweek (1.0 FTE). You can also work more or fewer hours in exchange for more or fewer free hours. For example, with a 40-hour workweek, you save 96 extra free hours, and with a 36-hour workweek, you lose 96 hours.
- End-of-year bonus of 8.3% and 8% holiday allowance.
- Extensive opportunities for personal and professional development.
- In total a 6 months contract duration.
Where will you be working?
At the University of Groningen (UG), researchers from all fields of academia and technology are working on academic challenges and societal questions. Lecturers prepare their students for meaningful careers within or outside the academic world. Interdisciplinary research and teaching, sharing of knowledge, collaboration with businesses, government institutions, and societal organizations are aspects that are of the utmost importance to this European top university. The UG aims to be an open academic community with an inclusive and safe working climate that invites you to add your value.
The Faculty of Science and Engineering (FSE) provides teaching and research across a wide range of disciplines, from physics and biology to artificial intelligence, mechanical engineering, and pharmacy. In close collaboration with partners from industry, healthcare, and society, we contribute to the urgent challenges of our time, such as energy, sustainability, digitization, and medical technology. Our community is open and informal, with more than 7,000 students, 1,000 PhD students, and 1,400 staff members from all over the world. If you would like to learn more about the Faculty of Science and Engineering, visit rug.nl/fse.
The vacancy is within the group of Assis. Prof. Dr. Wen Wu at the Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, which is located on the UMCG campus in Groningen.
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Application procedure
After submitting your application, you will receive a confirmation by email.
The selection committee assesses your application and you will be notified as soon as possible whether you are invited for an interview.
We would like to get to know each other better in a first interview, which can take place either online or on location.
We may schedule a second interview with you. Depending on the position, this interview can be complemented with an assessment or guest lecture.
After a positive interview, we will discuss the terms of employment together. When everything is completed, we are happy to welcome you at the University of Groningen!
Interested?
Does this vacancy appeal to you? If so, click on the button below and apply straightaway.
Please add the following documents to your application:
-
CV
-
cover letter
Do you have any questions or need more information?
-
Questions about the content of the job?
Wen Wu
Assistant Professor
w.y.wu@rug.nl -
Questions about your application process?
Friso Salverda
Human Resources Adviser
f.d.salverda@rug.nl
Information about applying
When scheduling meetings, we will take your schedule into account as much as possible.
The University of Groningen considers social safety important. We strive to be a university where staff and students feel respected and at home, regardless of differences in background, experiences, perspectives, and identity. For more information, see also our page about our diversity policy.
Acquisition is not appreciated.
Our selection procedure follows the guidelines of the NVP Application Code.
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